2,4,6-三甲基苯甲醛的制备方法

主要介绍了以均三甲苯为原料用不同的酰化剂进行酰化反应合成2,4,6-三甲基苯甲醛的方法,酰化剂分别为一氧化碳、丙酮氰醇、氰化锌、甲醛、格氏试剂和三氯乙醛,通过对各种酰化剂酰化反应条件与结果的比较,讨论了各种方法的优缺点,均三甲苯与三氯乙醛及一氧化碳酰化反应制备2,4,6-三甲基苯甲醛的方法具有收率高和原料易得的特点,具有较好的工业化前景;同时对2,4,6-三甲基苯甲酰氯还原加氢法进行了简述。

Preparation Method of 2,4,6-Trimethylbenzaldehyde

Chemical synthesis of 2, 4, 6-trimethylbenzaldehyde from mesitylene and various acylating agent was introduced. Acylating agents were carbon monoxide, acetone cyanohydrio, zinc cyanide, formaldehyde, Grignard reagent and chloral, respectively. The advantages and disadvantages of these methods are discussed through the reaction conditions and resuhs comparison among every, acylating agent. The preparation method of 2, 4, 6- trimethylbenzaldehyde by aeylation reaction between mesitylcne with carbon monoxide or chloral has preferable industrialization foreground due to high yield and raw material being easily obtained. In addition, the reductive-hydrogenation method of 2, 4, 6-trimethylbenzoyl chloride was briefly introduced.