Self-assembled magnetic bead biosensor for measuring bacterial growth and antimicrobial susceptibility testing |
| |
Authors: | Kinnunen Paivo McNaughton Brandon H Albertson Theodore Sinn Irene Mofakham Sima Elbez Remy Newton Duane W Hunt Alan Kopelman Raoul |
| |
Affiliation: | University of Michigan, Department of Chemistry, 930 N. University, Ann Arbor, MI 48109-1055, USA. pkkinn@umich.edu. |
| |
Abstract: | Bacterial antibiotic resistance is one of the major concerns of modern healthcare worldwide, and the development of rapid, growth-based, antimicrobial susceptibility tests is key for addressing it. The cover image shows a self-assembled asynchronous magnetic bead rotation (AMBR) biosensor developed for rapid detection of bacterial growth. Using the biosensors, the minimum inhibitory concentration of a clinical E. coli isolate can be measured within two hours, where currently tests take 6-24 hours. A 16-well prototype is also constructed for simple and robust observation of the self-assembled AMBR biosensors. |
| |
Keywords: | magnetic beads biosensors self‐assembly asynchronous magnetic bead rotation antimicrobial susceptibility testing |
本文献已被 PubMed 等数据库收录! |
|