Effects of basic modifiers on sfe efficiencies of ephedrine derivatives from plant matrix |
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Authors: | Jin Yeol Kim Ki-Pung Yoo |
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Affiliation: | (1) Department of Chemical Engineering, Sogang University, C.P.O. Box 1142, Seoul, Korea |
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Abstract: | The effect of basified modifiers in supercritical CO2 (SCF-CO2) such as diethylamine has been investigated on the SFE efficiencies of ephedrine derivatives (e.g. methylephedrine, norephedrine,
ephedrine, and pseudoephedrine) from aerial parts ofEphedra sinica. The addition of basified modifiers in SCF-CO2 showed a greater enhancement of SFE efficiency of ephedrine derivatives than pure modifiers. These results might be due to
the fact that the salts ofEphedra alkaloids (insoluble in CO2) in plant tissues would be changed to their free bases (freely soluble in CO2) by basified modifiers such as diethylamine in methanol. In addition to enhancing the solubilities, it could increase the
degree of desorption of the compounds from plant matrix. Also, the SCF-CO2 modified with methanol basified with diethylamine showed a difference of extractability of ephedrine and its diastereomer,
pseudoephedrine.
This paper was presented at The 5th International Symposium on Separation Technology-Korea and Japan held at Seoul between
August 19 and 21, 1999. |
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Keywords: | Supercritical CO2 Basified Modifier Ephedrine Derivatives Ephedra sinica |
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