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Early attentional deficits in an attention-to-prepulse paradigm in ADHD adults.
Authors:Conzelmann  Annette; Pauli  Paul; Mucha  Ronald F; Jacob  Christian P; Gerdes  Antje B M; Romanos  Jasmin; B?hne  Christina G; Heine  Monika; Boreatti-Hümmer  Andrea; Alpers  Georg W; Fallgatter  Andreas J; Warnke  Andreas; Lesch  Klaus-Peter; Weyers  Peter
Abstract:Adults with attention-deficit/hyperactivity disorder (ADHD) were examined for early and late attentional processes as a function of controlled attention. The test paradigm was the attentional modulation of prepulse inhibition (PPI; early controlled attentional processing) and prepulse facilitation (PPF; late controlled attentional processing). In 49 patients and 49 controls, the authors measured acoustic startle responses to 96-dB startle pulses preceded 120, 240 (for PPI), 2,000, and 4,500 (for PPF) ms by a 68-dB prepulse noise. Geometric figures signaled that prepulses were to be ignored or attended to (automatic vs. controlled attention). ADHD patients exhibited deficits in prepulse modulation, but these reflected an interaction of controlled attention and time of information processing. Normal PPI and PPF occurred under all conditions except for controlled attentional modulation of PPI. Attention deficits in ADHD patients may reflect not general derangements in information processing or ability to attend but, rather, selective disturbances of controlled attention during early information processing. (PsycINFO Database Record (c) 2010 APA, all rights reserved)
Keywords:ADHD  attention  prepulse facilitation  prepulse inhibition  startle response
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