核酸适体靶向红荧烯有机纳米探针用于肿瘤成像研究

近二十年来，肿瘤在我国的发生率和死亡率呈现不断增高的趋势。若能早期发现癌变位点并及时对其进行靶向治疗，将有助于提高癌症的治愈率。伴随着纳米技术的发展，用于癌症早期诊断成像和治疗的纳米材料的开发也得到了人们的广泛关注。文章介绍了一种基于核酸适体靶向肿瘤细胞的有机荧光纳米探针，其制备过程快速简便，所制得的纳米颗粒不仅表现出优异的靶向能力，而且具有良好的生物相容性和稳定性，该研究为肿瘤的靶向诊疗提供了有力工具。

Aptamer-Functionalized Rubrene-Nanoprobes for Tumor-Targeted Imaging

Over the past twenty years, the morbidity and mortality of tumor in our country was increasing. If the the cancer could be detected at early stages, targeting therapy would be performed which contribute to improve the cure rate of cancer. With the development of nanotechnology, nanomaterials used in early diagnosis of cancer imaging and treatment have aroused wide concern. A kind of organic fluorescent nanoprobes based on aptamer for tumor-targeted imaging with rapid, simple synthetic process was developed in this research. The nanoprobes not only exhibit excellent targeting function but also have good biocompatibility and stability, and provide a powerful tool for further tumor diagnosis and treatment.