The Role of Exosomes in Cancer Progression |
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| Authors: | Beta Soltsz Gergely Bugly Nikolett Nmeth Melinda Szilgyi Ondrej Ps Tomas Szemes Istvn Balogh Blint Nagy |
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| Affiliation: | 1.Department of Human Genetics, Faculty of Medicine, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary; (G.B.); (N.N.); (M.S.); (I.B.); (B.N.);2.Geneton Ltd., 841 04 Bratislava, Slovakia; (O.P.); (T.S.);3.Comenius University Science Park, Comenius University, 841 04 Bratislava, Slovakia;4.Division of Clinical Genetics, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary |
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| Abstract: | Early detection, characterization and monitoring of cancer are possible by using extracellular vesicles (EVs) isolated from non-invasively obtained liquid biopsy samples. They play a role in intercellular communication contributing to cell growth, differentiation and survival, thereby affecting the formation of tumor microenvironments and causing metastases. EVs were discovered more than seventy years ago. They have been tested recently as tools of drug delivery to treat cancer. Here we give a brief review on extracellular vesicles, exosomes, microvesicles and apoptotic bodies. Exosomes play an important role by carrying extracellular nucleic acids (DNA, RNA) in cell-to-cell communication causing tumor and metastasis development. We discuss the role of extracellular vesicles in the pathogenesis of cancer and their practical application in the early diagnosis, follow up, and next-generation treatment of cancer patients. |
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| Keywords: | liquid biopsy exosomes biomarkers cell-free nucleic acids cancer |
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