植物甾醇酯和葛根素复合微胶囊的制备工艺优化

以植物甾醇酯和葛根素为芯材，阿拉伯胶和β-环状糊精为壁材，采用喷雾干燥法制备植物甾醇酯葛根素复合微胶囊。考察了乳化剂配比、乳化剂用量、固形物含量、芯壁比、壁材比对乳化液稳定性的影响，以及进风温度、出风温度、均质压力对微胶囊化效率的影响，通过单因素试验和正交试验，确定复合微胶囊的最佳工艺参数。结果显示，复合微胶囊的最佳工艺条件为：乳化剂（蔗糖酯-单甘酯）配比6∶4（g/g）、乳化剂用量0.7%（质量分数）、固形物含量20%（质量分数）、芯壁比0.25∶1（g/g）、壁材（阿拉伯胶和β-环状糊精）比5∶5（g/g）、进风温度180 ℃、出风温度75 ℃、均质压力25 MPa。在此工艺条件下复合微胶囊中植物甾醇酯的包埋率为89.04%，葛根素包埋率为80.15%，产品为乳白色、细小均匀的粉末，气味纯正，密度0.568 g/mL，溶解率95.11%，水分含量3.57%，贮藏稳定性提高。

Optimization of Preparation Process for Blend Microcapsules of Phytosterol Esters and Puerarin

Using gum arabic and β-cyclodextrin as wall materials, blend microcapsules of phytosterol esters and puerarin
were prepared by a spray drying method. The influences of emulsifier composition, emulsifier dosage, solids content, core
material-to-wall material ratio, and gum Arabic-to-β-cyclodextrin ratio on emulsion stability were investigated as well as
the influences of inlet temperature, outlet temperature and homogenization pressure on microencapsulation efficiency. The
optimum processing parameters for the preparation of composite microcapsules were determined by combined use of single
factor and orthogonal array experiments as follows: emulsifier dosage (sucrose ester : monoglyceride = 6:4, g/g), 0.7%; solid
content, 20%; core material/wall material ratio, 0.25:1; wall material composition, acacia senegal:β-cyclodextrin = 5:5; inlet
temperature, 180 ℃; outlet temperature, 75 ℃; and homogenization pressure, 25 MPa. Under the optimum conditions, the
microencapsulation efficiency of phytostetol esters and puerarin were 89.04% and 80.15%, respectively. The composite
microcapsule was a milky white, uniform fine powder that smells pure. It had a moisture of 3.57%, density of 0.568 g/mL
and solubility of 95.11%, and exhibited high storage stability.