| 植物多酚通过Nrf2/ARE信号通路抗氧化作用研究进展 |
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| 引用本文： | 廖 霞,郑少杰,卢可可,肖星凝,吴素蕊,明 建.植物多酚通过Nrf2/ARE信号通路抗氧化作用研究进展[J].食品科学,2016,37(7):227-232. |
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| 作者姓名： | 廖 霞 郑少杰 卢可可 肖星凝 吴素蕊 明 建 |
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| 作者单位： | 1.西南大学食品科学学院，重庆 400715；2.中华全国供销合作总社昆明食用菌研究所，云南 昆明 650223；3.重庆市特色食品工程技术研究中心，重庆 400715 |
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| 摘 要： | 植物多酚是植物体内重要的次生代谢产物，是重要的天然抗氧化剂，能够清除自由基和淬灭活性氧。Nrf2（NF-E2-related factor 2）/抗氧化反应元件（antioxidant response element，ARE）信号通路是增强机体抗氧化功能最重要的保护性信号途径，在细胞抵御氧化应激机制中有着重要的地位，是抗氧化研究领域的热点。本文综述了Nrf2/ARE信号通路的组成及其调节机制，总结植物多酚通过该信号通路增强机体抗氧化应激能力，减少细胞凋亡、参与神经保护、延缓衰老和减少氧化损伤等的能力，以期为植物多酚应用于抗氧化保健食品和药品的开发提供一定依据。
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| 关 键 词： | 植物多酚 Nrf2/ARE 信号通路 抗氧化活性 |
Plant Polyphenols Exert Antioxidant Activity of by Nrf2/ARE Signaling Pathway: A Review |
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| LIAO Xia,ZHENG Shaojie,LU Keke,XIAO Xingning,WU Surui,MING Jian.Plant Polyphenols Exert Antioxidant Activity of by Nrf2/ARE Signaling Pathway: A Review[J].Food Science,2016,37(7):227-232. |
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| Authors: | LIAO Xia ZHENG Shaojie LU Keke XIAO Xingning WU Surui MING Jian |
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| Affiliation: | 1. College of Food Science, Southwest University, Chongqing 400715, China; 2. Kunming Edible Fungi Institute of All China
Federation of Supply and Marketing Cooperatives, Kunming 650223, China; 3. Chongqing Engineering Research Center of Regional
Food, Chongqing 400715, China |
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| Abstract: | Polyphenols are important secondary metabolites widely distributed in the plant kingdom. They are well known asantioxidants which reduce ROS-induced damage and scavenge free radicals. The Nrf2/ARE signaling pathway is one of themost important pathways involved in preservation of antioxidant activity and defense against oxidative stress release in cells.This review outlines the composition and modulatory mechanism of the Nrf2/ARE signaling pathway. Plant polyphenolsenhance oxidative stress resistance, reduce apoptosis, provide nerve protection, resist aging and mitigate oxidative damagethrough the Nrf2/ARE signaling pathway. All these evidence suggests that plant polyphenols have great potentials to beutilized in foods and drugs. |
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| Keywords: | plant polyphenols Nrf2/ARE signaling pathway antioxidant activity |
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