微生物代谢组学研究及应用进展

代谢组学是系统生物学的重要研究领域，具有独特的优势。近年来，微生物代谢组学这一新兴领域已受到广泛的关注，它不仅提供了代谢途径的广阔图谱，而且还阐明了微生物与宿主之间的相互作用机制。本文主要阐述了微生物代谢组学研究过程中样品制备、代谢物分析鉴定以及数据分析等主要研究方法，介绍了微生物代谢组学在乳酸菌、肠道菌群、病原菌以及食品和营养学研究领域中的研究进展及其应用，并讨论了微生物代谢组学中的主要问题和发展趋势。

Progress in Microbial Metabolomics and Its Application

Metabolomics is a significant research field of system biology with unique advantages. Recently, microbial
metabolomics has gained much attention. It not only offers a broad picture of metabolic pathways, but also elaborates the
mechanisms of the interaction between microbes and their hosts. This article summarizes the major methods involved in the
research process of microbial metabolomics, including sampling preparation, analysis, metabolite identification and data
analysis. Besides, this review also introduces the development and application of microbial metabolomics in research on
lactic acid bacteria, the gut microbiota, pathogens, food science and nutrition. Moreover, we discuss the major issues and
future trends in microbial metabolomics.