北五味子总木脂素对C57BL/6小鼠高脂血症的影响

目的：探讨北五味子总木脂素（Schisandra Chinensis lignans，SCL）对高脂饮食诱导的高脂血症小鼠血脂调节的影响。方法：雄性C57BL/6小鼠60 只，随机抽取30 只设为正常对照组（CON）和正常＋SCL 组（CON＋SCL 100 mg/kg），每组15 只，以普通饲料喂养。其余30 只小鼠以高脂饲料喂养4 周，确定高脂血症小鼠模型建立成功后，将小鼠随机分为模型组和SCL治疗组（模型＋SCL 100 mg/kg），全部小鼠连续灌胃给药12周后检测血清中总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）、低密度脂蛋白胆固醇（lowdensity lipoprotein cholesterol，LDL-C）和高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）含量并计算动脉粥样硬化指数（atherosclerosis index，AI），检测小鼠脂/体比，检测肝组织中TC和TG含量。结果：与正常对照组比较，模型组小鼠血清中TC、TG、LDL-C、AI及脂/体比均显著增高（P＜0.01），HDL-C含量降低，肝组织中TG和TC含量升高，与模型组比较，SCL 显著降低了小鼠血清TC、TG、LDL-C、AI及脂/体比（P＜0.01或P＜0.05），升高了HDL-C含量，并降低了肝组织中TC和TG含量（P＜0.01）。结论：SCL 可以减轻高脂血症小鼠脂肪含量，对小鼠高脂血症具有一定的治疗作用。

Effect of Schisandra chinensis Lignans on Hyperlipidemia in C57BL/6 Mice

Objective: To investigate the regulatory effect of Schisandra chinensis lignans (SCL) on hyperlipidemia induced
by high-fat diet in mice. Methods: Among 60 male C57BL/6 mice, 30 mice were randomly divided into normal control
group (CON) and normal + SCL group (CON + SCL 100 mg/kg) of 15 animals each and fed with normal diet. The rest of
the mice were fed with high-fat diet for 4 weeks. After the hyperlipidemic mouse model was successfully established, the
mice were randomly divided into model group (Model) and SCL-treated group (Model + SCL 100 mg/kg). All mice were
intragastrically administrated with corresponding agents for 12 weeks. Then, total cholesterol (TC), triglyceride (TG), low density
lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) concentrations in serum were detected and the
atherosclerosis index (AI) was calculated. The ratio of lipid to body weight, and TC and TG levels in liver tissue were determined.
Results: Compared with the normal control group, TC, TG and LDL-C concentrations in serum, AI and lipid/body weight ratio
and TC and TG concentrations in liver tissue were significantly increased (P < 0.01), and HDL-C concentration was reduced in
the model group. TC, TG and LDL-C contents, AI and lipid/body ratio and TC and TG in liver tissue were decreased (P < 0.01
or P < 0.05), and HDL-C was elevated in mice treated with SCL compared with those in the model group. Conclusion: SCL can
reduce fat mass in hyperlipidemic mice, suggesting its therapeutic effect on hyperlipidemia.