Plasma levels of transforming growth factor beta 1 in chronic liver disease |
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Authors: | A Hayasaka N Suzuki E Fukuyama Y Kanda |
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Affiliation: | Department of Medicine, University of Wales College of Medicine, Cardiff. |
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Abstract: | We describe the case of a 30-year-old female patient with a 7-year history of multiple sclerosis, who presented with an 18-month history of secondary amenorrhoea and vague symptoms which included poor sleep and impaired concentration. Endocrine investigations revealed hypogonadotrophic hypogonadism and GH deficiency, a probable consequence of a hypothalamic plaque. This is the first report of hypogonadotrophic hypogonadism and GH deficiency occurring in conjunction with multiple sclerosis. As such, it should raise suspicion of endocrine dysfunction occurring in a condition with such a vast spectrum of disability as multiple sclerosis. |
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