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| 强脉冲光对胶原蛋白生物效应的实验研究 | |
| 引用本文： | 李康英,马少吟,康新任,邓寿松. 强脉冲光对胶原蛋白生物效应的实验研究[J]. 应用激光, 2008, 28(1): 66-69 |
| 作者姓名： | 李康英 马少吟 康新任 邓寿松 |
| 作者单位： | 1. 暨南大学附属第一医院激光科,广东广州,510630 2. 广州市皮肤病防治所,广东,广州510095 3. 广州激光技术应用研究所,广东,广州510115 |
| 摘 要： | 目的:探讨强脉冲光对胶原蛋白的生物效应与治疗皮肤光老化的作用机制.方法:采用波长640-1200nm的强脉冲光照射豚鼠背部皮肤;能量密度为30J/cm2,单脉冲发射,脉宽5ms.分别于照光后第1d、8d、15d、30d及45d切取皮肤样本,进行HE染色、苦味酸染色观察组织学改变;测量照光区皮肤羟脯氨酸的含量.结果:组织病理显示照光区从第8d起至第45d成纤维细胞增多,胶原纤维排列由疏松逐渐致密,明显强于非照光区.照光区皮肤羟脯氨酸含量从第8d起至第45d持续高于非照光区,具有显著性差异(p<0.001).结论:强脉冲光照射豚鼠皮肤后可刺激胶原蛋白增加,进而改善皮肤弹性,并至少能维持8周以上的时效性,为强脉冲光治疗皮肤光老化预测有效期的时效性与设定治疗间期提供参考依据. |
| 关 键 词： | 强脉冲光 胶原蛋白 生物效应 强脉冲光 胶原蛋白 生物效应 实验 研究 Light Biological Effect Study 参考依据 有效期 预测 时效性 皮肤弹性 改善 刺激 显著性差异 羟脯氨酸含量 疏松 纤维排列 成纤维细胞 |
| 收稿时间： | 2007-10-20 |
| 修稿时间： | 2007-10-20 |
Experimental Study of Collagens Biological Effect by Intense Pulsed Light |
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| Li Kangying,Ma Shaoyin,Kang Xinren,Deng Shousong. Experimental Study of Collagens Biological Effect by Intense Pulsed Light[J]. Applied Laser, 2008, 28(1): 66-69 | |
| Authors: | Li Kangying Ma Shaoyin Kang Xinren Deng Shousong |
| Affiliation: | Li Kangying,Ma Shaoyin,Kang Xinren,Deng ShousongDepartment of Laser,the First Affiliated Hospital of JiNan University,Guangzhou,Guangdong 510630,China |
| Abstract: | Objective:To study collagens biological effect by intense pulsed light.To explain the treatment mechanism of Intense Pulsed Light(IPL) on sun-damaged human skin.Methods: After back skin of cavia cobaya was irradiated by IPL irradiation,histological change of the skin would be observed with HE Stains and Nitroxanthic Acid Stains.The content of hydroxyproline would be carried out.Treatment parameters of IPL were 640-1200nm wavelength,single-stacked pulse with energy density of 30J/cm2,pulse width 5ms.Results:... |
| Keywords: | Intense pulsed light(IPL) collagen biological effect |
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