| 三氟乙酸钠对卤代芳烃的三氟甲基化反应 |
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| 引用本文： | 常瑛,蔡春. 三氟乙酸钠对卤代芳烃的三氟甲基化反应[J]. 精细化工, 2005, 22(4): 311-313 |
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| 作者姓名： | 常瑛 蔡春 |
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| 作者单位： | 南京理工大学,化工学院,江苏,南京,210094;南京理工大学,化工学院,江苏,南京,210094 |
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| 摘 要： | 在惰性气体保护及碘化亚铜催化的条件下,三氟乙酸钠与溴苯、碘苯以及碘代甲苯和碘代硝基苯等卤代芳烃反应,制备得到相应的三氟甲基化合物。确定了该方法的适宜条件:溶剂为N,N 二甲基甲酰胺,n(PhI)∶n(CuI)∶n(CF3COONa) =1∶2∶8, 160℃下搅拌反应 4h,产物收率达 77 8%。
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| 关 键 词： | 卤代芳烃 三氟甲基化 三氟乙酸钠 |
| 文章编号： | 1003-5214(2005)04-0311-03 |
Trifluoromethylation of Aromatic Halides with Sodium Trifluoroacetate |
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| CHANG Ying,CAI Chun. Trifluoromethylation of Aromatic Halides with Sodium Trifluoroacetate[J]. Fine Chemicals, 2005, 22(4): 311-313 |
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| Authors: | CHANG Ying CAI Chun |
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| Affiliation: | CHANG Ying,CAI Chun~* |
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| Abstract: | In the presence of copper(Ⅰ) iodide as the catalyst and under the protection of inert gas,aromatic halides including bromobenzene,iodobenzene,iodotuluene and iodonitrobenzene reacted with sodium trifluoroacetate to give the corresponding trifluoromethylated compounds in moderate to good yields.The optimum reaction conditions were determined.Thus,using N,N-dimethylformamide as solvent,mole ratio n(PhI)∶n(CuI)∶n(CF_3COONa)=1∶2∶8,stirring for 4 h at 160 ℃ under nitrogen,the yield amounted to 77.8%. |
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| Keywords: | aromatic halide trifluoromethylation sodium trifluoroacetate |
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