| 4-氨基-5-(3,4,5-三甲氧基苄基)嘧啶-2-醇的合成 |
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| 引用本文： | 王锦贵,吴建国,李菊平.4-氨基-5-(3,4,5-三甲氧基苄基)嘧啶-2-醇的合成[J].山东化工,2010,39(5):19-21. |
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| 作者姓名： | 王锦贵 吴建国 李菊平 |
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| 作者单位： | 1. 山东省寿光市公安消防大队,山东,寿光,262700
2. 山东寿光富康制药有限公司,山东,寿光,262700 |
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| 摘 要： | 以化合物3-苯基氨基-2-(3,4,5-三甲氧基苄基)丙烯腈为主要原料,以甲醇钠为缩合剂,与尿素反应得目标化合物4-氨基-5-(3,4,5-三甲氧基苄基)嘧啶-2-醇,反应收率达到76.3%。经HPLC检测,纯度达98.6%。用FT-IR、1HNMR和元素分析对目标化合物的结构进行了表征。
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| 关 键 词： | 4-氨基-5-（3 4 5-三甲氧基苄基）嘧啶-2-醇 胞嘧啶 丙烯腈 合成 |
Synthesis of 4-Amino-5-(3,4,5-trimethoxybenzyl)Pyrimidin-2-ol |
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| WANG Jin-gui,WU Jian-guo,LI Ju-ping.Synthesis of 4-Amino-5-(3,4,5-trimethoxybenzyl)Pyrimidin-2-ol[J].Shandong Chemical Industry,2010,39(5):19-21. |
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| Authors: | WANG Jin-gui WU Jian-guo LI Ju-ping |
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| Affiliation: | WANG Jin - gui , WU Jian - guo, LI Ju -ping( 1. Shandong Shouguang Fire Brigade of Public Security,Shouguang 262700,China; 2. Shandong Shouguang Fukang Pharmaceutical Co. , Ltd. ,Shouguang 262700,China) |
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| Abstract: | The target compound 4 - amino - 5 - （3,4,5 - trimethoxybenzyl） pyrimidin - 2 - ol was prepared from 3 - phenylamino - 2 - （ 3,4,5 - trimethoxybenzyl ） acrylonitrile and urea under the conditions of sodium methoxide through the condensation reaction. The yield of the reaction was 76.3%. The purity was 98.6% of the weight by HPLC. The target product was characterized by means of FT - IR, 1 HNMR and elemental analysis. |
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| Keywords: | 4 - amino - 5 - （ 3 4 5 - trimethoxybenzyl ） pyrimidin - 2 - ol cytosine acrylonitrile synthesis |
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