| 二元取代壳聚糖季铵盐的抗菌活性 |
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| 引用本文： | 赵希荣,夏文水.二元取代壳聚糖季铵盐的抗菌活性[J].食品与生物技术学报,2006,25(5):55-61. |
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| 作者姓名： | 赵希荣 夏文水 |
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| 作者单位： | 1. 江南大学,食品学院,江苏,无锡,214036;淮阴工学院,食品工程系,江苏,淮安,223001
2. 江南大学,食品学院,江苏,无锡,214036 |
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| 基金项目： | 江苏省高技术研究发展计划项目 |
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| 摘 要： | 对合成的系列单取代和双取代壳聚糖季铵盐进行了抗菌试验。实验结果表明，单取代壳聚糖季铵盐抗菌活性弱于双取代壳聚糖季铵。在双取代壳聚糖季铵盐中，O-季铵化-N-壳聚糖内桂醛席夫碱的最低抑菌浓度（MIC）最小，对金黄色葡萄球菌和大肠杆菌的MIC分别达到了为0．01％和0．02％。试验结果表明，壳聚糖衍生物抗菌活性与结构之间有一定的构效关系。
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| 关 键 词： | 二元取代壳聚糖季铵盐 抗菌活性 构效关系 |
| 文章编号： | 1673-1689(2006)05-0055-06 |
| 修稿时间： | 2005年5月10日 |
Antibacterial Activity of Binary Substituted Quaternary Ammonium Salts of Chitosan |
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| ZHAO Xi-rong,XIA Wen-shui.Antibacterial Activity of Binary Substituted Quaternary Ammonium Salts of Chitosan[J].Journal of Food Science and Biotechnology,2006,25(5):55-61. |
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| Authors: | ZHAO Xi-rong XIA Wen-shui |
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| Abstract: | The antibacterial activities of a series of single and binary-substituted quaternary ammonium salts of chitosan were evaluated.The results showed that the antimicobial activity of single-substitute quaternary ammonium salts of chitosan were lessen than that of the binay-substitute derivatives.Among of the binary-substitute derivatives,the MIC of O-quaternized N-chitosan-cinnamaldehyde schiff's bases was the best.The MIC value of the series derivatives to Staphylococcus aureus and Escherichia coli were respectively 0.01% and 0.025%.Based on these results,it is concluded that there is some relationship between antibacterial activity and structure of chitosan derivatives. |
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| Keywords: | binary-substituted quaternized chitosan antibacterial activity structure-activity relationship |
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