| 头孢菌素中间体THZ的合成与表征 |
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| 引用本文： | 陈建 奚强. 头孢菌素中间体THZ的合成与表征[J]. 武汉化工学院学报, 2006, 28(2): 5-7,11 |
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| 作者姓名： | 陈建 奚强 |
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| 作者单位： | 武汉化工学院化工与制药学院,湖北省新型反应器与绿色化学工艺重点实验室,湖北武汉430074 |
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| 摘 要： | 2-（3苄基7-羰基-4-噻-2，6-二唑双环[3．2．0]庚-2-烯-6-基）-3-甲基-3-丁烯酸二苯甲酯（THZ）是制备多种头孢菌素的重要中间体．本文以青霉素G钾盐（PGK）为原料，经酯化、氧化和开环制得THZ，通过元素分析、IR、^1H NMR对其结构进行表征，并用HPLC测定其含量．采用本方法合成THZ，其工艺简单、可靠，适于工业化．
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| 关 键 词： | 青霉素 头孢菌素 THZ |
| 文章编号： | 1004-4736（2006）02-0005-03 |
| 收稿时间： | 2005-04-08 |
| 修稿时间： | 2005-04-08 |
Preparation and character of cephalosporin intermediate THZ |
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| CHEN Jian, XI Qiang. Preparation and character of cephalosporin intermediate THZ[J]. Journal of Wuhan Institute of Chemical Technology, 2006, 28(2): 5-7,11 |
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| Authors: | CHEN Jian XI Qiang |
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| Affiliation: | School of Chemical Engineering and Pharmacy,Wuhan Institute of Chemical Technology, Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology,Wuhan 430074,China |
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| Abstract: | Diphenylmethyl 2-(3-benzyl-7-oxo-4-thia-2,6-diazabicyclo[3.2.0]hept-2-en-6-yl)-3-methyl[CD*2]3-butenoate(THZ) is an important inter-mediate for the manufacture of cephalosporin.This article describes the preparation procedure of THZ via penicillin G potassium salt.The product was characterized through element analysis,IR and 1H NMR,and assayed by HPLC.The preparation procedure is simple and feasible,which can meet the industrial requirement. |
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| Keywords: | penicillin eephalosporin THZ |
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