The tau mutation affects temperature compensation of hamster retinal circadian oscillators |
| |
Authors: | G Tosini M Menaker |
| |
Affiliation: | Department of Biology, University of Virginia, Charlottesville 22903, USA. |
| |
Abstract: | Neural retinas of the golden hamster (Mesocricetus auratus) express circadian rhythms of melatonin synthesis when cultured in constant darkness. Retinas from wild-type hamsters synthesize melatonin with a period close to 24 h, while retinas obtained from hamsters homozygous for the circadian mutation tau, which shortens the free-running period of the circadian activity rhythm by 4 h, synthesize melatonin with a period close to 20 h. The retinal circadian oscillators of both wild-type and tau mutant hamsters are temperature compensated; however, temperature compensation is adversely affected by the mutation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|