富硒沼泽红假单胞菌G3 菌与牛初乳复配改善小鼠免疫功能的作用研究

目的：探讨富硒沼泽红假单胞菌G3 菌(简称富硒G3 菌)与牛初乳复配对小鼠免疫功能的影响。方法：将富G3 菌与牛初乳复配形成富硒牛初乳，用环磷酰胺构建小鼠免疫低下模型，对免疫低下小鼠灌胃富硒G3 菌、牛初乳和富硒牛初乳，50d 后测定各组小鼠脏器指数、白细胞数、T 淋巴细胞阳性率、血清SOD 酶活性、全血GSH-Px活性，同时计算平均每日进食饲料质量与体质量增加量的比值。结果：富硒G3 菌、牛初乳、富硒牛初乳均能提高免疫低下小鼠对饲料的利用率，能提高免疫低下小鼠SOD、GSH-Px 活性、白细胞数和T 淋巴细胞阳性率，其中富硒牛初乳高剂量组效果最为明显，说明富硒牛初乳高剂量组能显著增强小鼠的免疫功能。

Combined Effect of Bovine Colostrumson and Selenium-enriched Rhodopseudomonas palustris G3 on Immune Function in Mice

In order to investigate the effect of selenium-enriched bovine colostrumson on immune function of immunodepressed mice induced by cyclophosphamide, selenium-enriched Rhodopseudomonas palustris G3 (hereinafter called selenium-enriched G3) was mixed with bovine colostrumson to prepare selenium-enriched bovine colostrumson. The immunodepressed mice were treated with selenium-enriched G3, bovine colostrumson and selenium-enriched bovine colostrumson, respectively. The administration was carried out once a day for 47 successive days after 3 days of adaptive feeding, and organ index, white blood cell number, T-cell population, the contents of SOD and GSH-Px in blood, and feed/gain ratio of mice were determined at the end of the administration. Results indicated that selenium-enriched G3, bovine colostrumson and selenium-enriched bovine colostrumson could increase the utilization efficiency of diet, enhance the activities of SOD and GSH-Px in blood, and improve mouse immune function. Compared with the control group, the selenium-enriched bovine colostrumson exhibited best improved immune at the high dosage.