Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model |
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| Authors: | VANINA ANDREA FONTANA MELISA SANCHEZ ELISA CEBRAL AND JUAN CARLOS CALVO |
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| Affiliation: | 1. Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
2. Laboratorio de Biología del Desarrollo, Instituto de Fisiología, Biología Molecular y Neurociencias, DBBE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
3. Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina. |
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| Abstract: | Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-β on the activity of two important metalloproteinases (MMP-2 and MMP-9) that are involved in extracellular matrix remodeling as well as the secretion of leptin, one of the reproductive hormones actively regulating their activity and secretion. We found that IL-1β activates matrix metalloproteinase activity as well as increases leptin secretion. We propose that this interleukin, through the regulation of leptin, in turn activates matrix metalloproteinases which results in an increased cytotrophoblast invasion. |
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| Keywords: | cytokines embryo implantation placenta extracellular matrix |
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