细胞因子疫苗的研究进展

细胞因子是由免疫细胞(单核巨噬细胞、T淋巴细胞、B淋巴细胞及NK细胞)及相关细胞(如血管内皮细胞、纤维母细胞等)产生的一类可调节细胞功能的高活性、多功能的多肽分子。在病理状态下,细胞因子在介导和调节自身免疫性疾病、慢性炎症、肿瘤及HIV感染中具有重要作用。细胞因子具有双重效应,既可抵御和治疗某些疾病,也可能导致和促进某些疾病的发生。细胞因子调节疗法有补充/添加疗法和阻断/拮抗疗法两类。早期细胞因子阻断/拮抗疗法是被动免疫抗细胞因子抗体,但此种疗法存在明显的缺陷和不足。主动免疫疫苗可激发体内产生自身细胞因子抗体,阻断细胞因子活性,是近年来细胞因子调节疗法的主要进展之一,本文对此领域的研究进展作一综述。

Advance in Research on Cytokine Vaccine

Cytokines are highly active and multi-functional polypeptides which may regulate the functions of cells,produced by immune cells such as mononuclear macrophages,T lymphocytes,B lymphocytes and NK cells,and other relevant cells such as vascular endothelial cells,and fibroblasts.At pathological status,cytokines play important roles in regulating and modulating autoimmune diseases,chronic inflammations,tumors and HIV infection.Cytokines may be used for the prevention and treatment of some diseases.However,they may also cause and promote the onsets of some diseases.Regulatory therapy with cytokines includes supplement /addition and blocking /antagonism.The blocking /antagonism therapy with cytokines at early stage is performed by passive immunization with antibodies against cytokines,which shows significant disadvantages and shortcomings.Active immunization with cytokine vaccine may stimulate the production of autoantibodies to block the activity of cytokines,which is one of the most important development in regulatory therapy with cytokines in recent years.The advance in research on cytokine vaccine is reviewed in this paper.