Faculty of Chemistry, Biochemistry I, Bielefeld University, Universit?tsstrasse 25, 33615 Bielefeld (Germany), Fax: (+49)?521‐106‐6014
Abstract:
Oxidation of a specific cysteine residue to Cα‐formylglycine is a novel post‐translational modification that is directed by a short recognition motif commonly found in pro‐ and eukaryotic sulfatases. As recently shown by C. Bertozzi and co‐workers, this system can be employed in protein engineering to equip proteins with genetically encoded aldehyde tags for site‐specific labeling, conjugation and immobilization.
