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Synthesis and Biological Characterisation of Novel N‐Alkyl‐Deoxynojirimycin α‐Glucosidase Inhibitors |
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| Authors: | Amy J Rawlings Hannah Lomas Adam W Pilling Dr Marvin J‐R Lee Dominic S Alonzi Dr J S Shane Rountree Dr Sarah F Jenkinson Dr George W J Fleet Prof Dr Raymond A Dwek Prof Dr John H Jones Dr Terry D Butters Dr |
| Affiliation: | 1. Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU (UK), Fax: (+44)?1865‐275216;2. Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA (UK) |
| Abstract: | Illuminating glucosidases : The shown photoaffinity probe for endoplasmic reticulum (ER) α‐glucosidases was found to be a highly potent inhibitor of α‐glucosidase I in vitro and equally effective at inhibiting cellular ER glucosidases, as determined by a free oligosaccharide (FOS) analysis.  |
| Keywords: | glycosylation imino sugars nitrophenyl oligosaccharides photolabile groups |