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Efficient separation of enantiomers by preferential crystallization in two coupled vessels |
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| Authors: | Martin Peter Elsner Grzegorz Ziomek Andreas Seidel‐Morgenstern |
| Affiliation: | 1. Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, 39106 Magdeburg, Germany;2. Chair for Chemical Process Engineering, Otto von Guericke University, Universit?tsplatz 2, 39106 Magdeburg, Germany |
| Abstract: | The focus of this work is to study the enantioseparation of conglomerate forming systems using an innovative configuration for preferential crystallization. Two batch crystallizers are coupled by an exchange of their liquid phases. In each vessel one of the two enantiomers is seeded initially and crystallizes subsequently. Compared with conventional single batch crystallization the exchange of the crystal free liquid phases between two crystallizers leads to an increase of the concentrations of the preferred enantiomers and therefore to an increase of the driving forces for the crystallization. This enhances the productivity of the process compared with the conventional operation. © 2009 American Institute of Chemical Engineers AIChE J, 2009 |
| Keywords: | enantioseparation crystallizer configurations productivity conglomerates compound forming systems threonine mandelic acid |