Synthesis and antimicrobial activity of metronidazole containing polymer and copolymers |
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| Authors: | El‐Refaie Kenawy Salem S Al‐Deyab Nihal Omar Shaker Baheya Mohamed El‐Sadek Abeer H B Khattab |
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| Affiliation: | 1. Department of Chemistry, Petrochemicals Research Chair, Faculty of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia;2. Department of Chemistry, Faculty of Science, Al‐Azhar University, Cairo, Egypt |
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| Abstract: | Homopolymer and copolymers containing metronidazole (MTZ) drug were synthesized. Acryloyl chloride was reacted with MTZ (drug) to produce monomer containing MTZ, and then the monomer was copolymerized with various amounts of methyl methacrylate. The produced monomer, homopolymer, and copolymers were characterized by elemental analysis, IR, and 1H‐NMR. The antimicrobial activities of the synthesized polymers were tested against Kelpsilic as fungal organisms, and Escherichia coli, Bacillus subitilus, and Pesudomonus areuginosa as bacteria organisms. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009 |
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| Keywords: | antimicrobial polymers metronidazole copolymers biocide |
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