University of Kentucky, Department of Pharmaceutical Sciences, College of Pharmacy, 725 Rose Street, Lexington, KY 40536‐0082 (USA), Fax: (+1)?859‐257‐7564
Abstract:
Last at last : The terminal step of the gilvocarcin V (GV) biosynthetic pathway is an unusual lactone formation. Here we show that the enzyme, GilR, dehydrogenates the hemiacetal moiety of pregilvocarcin V to the lactone found in GV by using covalently bound FAD.
