Identification,Quantification, and Determination of the Absolute Configuration of the Bacterial Quorum‐Sensing Signal Autoinducer‐2 by Gas Chromatography–Mass Spectrometry期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Identification,Quantification, and Determination of the Absolute Configuration of the Bacterial Quorum‐Sensing Signal Autoinducer‐2 by Gas Chromatography–Mass Spectrometry

Authors:	Verena Thiel Ramiro Vilchez Dr Helena Sztajer Dr Irene Wagner‐Döbler Prof Dr Stefan Schulz Prof Dr

Affiliation:	1. Institut für Organische Chemie, Technische Universit?t Braunschweig, Hagenring 30, 38106 Braunschweig (Germany), Fax: (+49)?531‐3915272;2. Helmholtz‐Zentrum für Infektionsforschung, Inhoffenstrasse 7, 38124 Braunschweig (Germany)

Abstract:	Sensing the signal : A gas chromatography–mass spectrometry (GC–MS) method for the analysis of the quorum‐sensing autoinducer‐2 is described. It allows, for the first time, the direct analysis and accurate determination of this highly water soluble signaling compound, which exists in complex equilibria. The application on the caries‐causing bacterium Streptococcus mutans is described.

Keywords:	carbohydrates gas chromatography mass spectrometry pheromones quorum sensing