Synthesis and in vitro Activity of Heterocyclic Inhibitors of CYP2A6 and CYP2A13, Two Cytochrome P450 Enzymes Present in the Respiratory Tract期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis and in vitro Activity of Heterocyclic Inhibitors of CYP2A6 and CYP2A13, Two Cytochrome P450 Enzymes Present in the Respiratory Tract

Authors:	Antoinette Chougnet Prof. Wolf‐D. Woggon Prof. Esther Locher Boris Schilling Dr.

Affiliation:	1. Department of Chemistry, University of Basel, St.‐Johanns‐Ring 19, 4052 Basel (Switzerland);2. Givaudan Schweiz AG, Fragrance Research, Ueberlandstrasse 138, 8600 Duebendorf (Switzerland), Fax: (+41)?44‐824‐29‐26

Abstract:	To be sniffed at : Several 1‐ and 2‐substituted 1H‐imidazoles and 2‐substituted oxazoles, oxazolines and pyrazines have been synthesized and tested as inhibitors of the cytochrome P450 enzymes CYP2A6 and CYP2A13. 1‐Substituted 1H‐imidazoles bearing short chains (pentyl, hexyl or hexenyl) were found to be potent inhibitors of both enzymes, and showed IC₅₀ values of about 2 μM .

Keywords:	CYP2A13 CYP2A6 cytochromes inhibitors respiratory tract