Scheduling dispensing and counting in secondary pharmaceutical manufacturing |
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Authors: | Michele Ciavotta Carlo Meloni Marco Pranzo |
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Affiliation: | 1. Instituto Tecnológico de Informática, Universidad Politécnica de Valencia, Ciudad Politécnica de la Innovación, Camino de Vera, E‐46022 Valencia, Spain;2. Dipartimento di Elettrotecnica ed Elettronica, Politecnico di Bari, Via E. Orabona, 4‐70125 Bari, Italy;3. Dipartimento di Ingegneria dell'Informazione, Università di Siena, Via Roma, 56‐53100 Siena, Italy |
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Abstract: | In this article, we describe a general methodology for operations scheduling in dispensing and counting departments of pharmaceutical manufacturing plants. The departments are modeled as a multiobjective parallel machines scheduling problem under a number of both standard and realistic constraints, such as release times, due dates and deadlines, particular sequence‐dependent setup times, machine unavailabilities, and maximum campaign size. Main characteristics of the methodology are the modularity of the solution algorithms, the adaptability to different objectives and constraints to fulfill production requirements, the easiness of implementation, and the ability of incorporating human experience in the scheduling algorithms. Computational experience carried out on two case studies from a real pharmaceutical plant shows the effectiveness of this approach. © 2009 American Institute of Chemical Engineers AIChE J, 2009 |
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Keywords: | scheduling operations management pharmaceutical industry rollout algorithm pilot method |
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