Neurite Outgrowth on Nanocomposite Scaffolds Synthesized from PLGA and Carboxylated Carbon Nanotubes |
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| Authors: | Hyun Jung Lee Ok Ja Yoon Do Hee Kim Yeong Mi Jang Hyun Woo Kim Won Bok Lee Nae‐Eung Lee Sung Su Kim |
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| Affiliation: | 1. Department of Anatomy and Cell Biology, College of Medicine Chung‐Ang University, Seoul 156‐756, Korea;2. School of Advanced Materials Science and Engineering and Center for Advanced Plasma Surface Technology Sungkyunkwan University, Suwon, Kyunggi‐do 440‐746, Korea |
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| Abstract: | Carbon nanotubes (CNTs) have been suggested as suitable materials for biomedical applications, especially in the neural area. It is essential not only to investigate the biocompatibility of CNTs with the neural system but also to determine proper methods for applying CNTs to neuronal growth. This work represents the first application of CNTs by electrospun poly(D ,L ‐lactic‐co‐glycolic acid) (PLGA) scaffolds for a neural system. We synthesized electrospun nanocomposites of PLGA and single‐walled carbon nanotubes functionalized by carboxylic acid groups (c‐SWNTs), and investigated neurite outgrowth from SH‐SY5Y cells on these nanocomposites as compared to that on fibrous PLGA alone. Cells on our PLGA/c‐SWNT nanocomposite showed significantly enhanced mitochondrial function and neurite outgrowth compared to cells on PLGA alone. We concluded that c‐SWNTs incorporated into fibrous PLGA scaffolds exerted a positive role on the health of neural cells. |
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| Keywords: | nanotubes neurons |
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