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Assessing Carbohydrate–Carbohydrate Interactions by NMR Spectroscopy: The Trisaccharide Epitope from the Marine Sponge Microciona prolifera |
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| Authors: | J Ignacio Santos Dr Adriana Carvalho de Souza Dr F Javier Cañada Dr Sonsoles Martín‐Santamaría Dr Johannis P Kamerling Prof Dr Jesús Jiménez‐Barbero Prof Dr |
| Affiliation: | 1. Centro de Investigaciones Biológicas, CIB–CSIC, 28040 Madrid (Spain);2. Bijvoet Center, Department of Bio‐Organic Chemistry, Utrecht University, 3584?CH Utrecht (The Netherlands);3. Departamento de Química, Facultad de Farmacia, Universidad San Pablo, CEU, 28668 Boadilla del Monte, Madrid (Spain) |
| Abstract: | Weak recognition processes : Weak calcium‐mediated carbohydrate–carbohydrate interactions have been detected by DOSY and TRNOESY NMR methods by employing a gold glyconanoparticle as a multivalent system. In addition, 3D models of trisaccharide‐CaII‐trisaccharide complexes based on results from molecular dynamics simulations are proposed.  |
| Keywords: | carbohydrate– carbohydrate interactions gold glyconanoparticles Microciona prolifera molecular dynamics NMR spectroscopy |