| 2,3-二甲基-N-氧化吡啶的合成 |
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| 引用本文： | 徐宝财,王关兴,辛秀兰,肖阳.2,3-二甲基-N-氧化吡啶的合成[J].精细化工,2007,24(7):681-683. |
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| 作者姓名： | 徐宝财 王关兴 辛秀兰 肖阳 |
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| 作者单位： | 北京工商大学,化学与环境工程学院,北京,100037 |
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| 基金项目： | 北京市自然科学基金
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北京市教委科技发展计划项目 |
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| 摘 要： | 以2,3-二甲基吡啶为起始原料,经氧化合成2,3-二甲基-N-氧化吡啶。比较了间氯过氧苯甲酸、过氧乙酸和过氧化氢3种氧化剂的氧化效果,确定了用过氧化氢为氧化剂的方法:用乙酸做溶剂,2,3-二甲基吡啶和双氧水在85℃反应25 h,收率达97%。该方法用双氧水作氧化剂,对环境污染小,且原子利用率高。产物经质谱和1HNMR表征。
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| 关 键 词： | 2 3-二甲基吡啶 2 3-二甲基-N-氧化吡啶 过氧化氢 医药原料 |
| 文章编号： | 1003-5214（2007）07-0681-03 |
| 修稿时间： | 2006-10-102007-02-07 |
Synthesis of 2,3-Dimethylpyridine-N-oxide |
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| XU Bao-cai,WANG Guan-xing,XIN Xiu-lan,XIAO Yang.Synthesis of 2,3-Dimethylpyridine-N-oxide[J].Fine Chemicals,2007,24(7):681-683. |
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| Authors: | XU Bao-cai WANG Guan-xing XIN Xiu-lan XIAO Yang |
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| Affiliation: | School of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing 100037, China |
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| Abstract: | 2,3-Dimethylpyridine-N-oxide was synthesized by oxidation of 2,3-dimethylpyridine.The oxidation effect of three oxidants,3-chloroperbenzoic acid,peracetic acid and hydrogen peroxide were compared and hydrogen peroxide was preferred.The mixture of 2,3-dimethylpyridine and hydrogen peroxide in acetic acid were stirred at 85 ℃ for 25 h to give 2,3-dimethylpyridineN-oxide in 97% yield.This process using hydrogen peroxide as oxidant is environmentally-friendly with high atomic efficiency.The product was characterized by MS and 1HNMR. |
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| Keywords: | 2 3 -dimethylpyridine 2 3-dimethylpyridine-N-oxide hydrogen peroxide drug materials |
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