Galanthamine interaction with mouse brain acetylcholinesterase in in vivo experiments

Armine treatment of mice against the background of preliminary galanthamine injection diminished the inhibition of the acetylcholinesterase of the brain caused by a reversible inhibitor. This effect was connected with the acetylcholine accumulation and the displacement by it of galanthamine from the active centres of the enzyme. Thus, a competitive character of galanthamine-acetylcholinesterase interaction was shown in vivo.