Differences in the long chain (sphingoid) base composition of sphingomyelin from rats bearing Morris hepatoma 7777 |
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Authors: | Merrill Alfred H Wang Elaine Wertz Philip W |
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Affiliation: | (1) Department of Biochemistry, Emory University School of Medicine, 30322 Atlanta, Georgia;(2) Marshall Dermatology Research Laboratory, University of Iowa College of Medicine, Iowa City, Iowa |
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Abstract: | The long chain bases of sphingomyelin from Morris hepatoma 7777 and host and control livers were analyzed by capillary gas
liquid chromatography. Sphingosine (18∶1) was the major long chain base of control livers (66.5%) and hepatomas (65.6%), but
hepatomas also had a high percentage (9.3 vs 4.4) of the 16∶1 homolog. Host liver had the most unusual long chain base composition,
with ca. equal 16∶1 (24.4%) and 18∶1 (21.4%) and high amounts of 20-carbon bases (9.2% 20∶0 and 15.3% 20∶1). These differences
may be related to the aberrant fatty acid metabolism known to occur in tumor-bearing animals. Such large perturbations in
the long chain base composition of hepatic sphingomyelin are unprecedented and could have a major impact on the properties
of host membranes. |
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