苯和氯苯衍生物氧化羟基化反应规律的研究

采用V2O5催化剂,30%H2O2为氧化剂,醋酸为溶剂,研究了苯、苯酚、氯苯、邻(间、对)二氯苯等氧化羟基化反应规律。结果表明:在实验条件下,苯酚氧化活性明显高于苯氧化活性,但易导致深度氧化;氯苯的氧化活性略高于苯;氯苯氧化羟基化反应中,氯的对位氧化的相对选择性约为邻位或间位相对选择性的4~5倍;二氯苯氧化羟基化反应的选择性受两个氯共同影响,某位置的相对选择性约等于每个氯单独存在时相对选择性的乘积。

STUDY ON OXIDATIVE-HYDROXYLATION OF BENZENE AND CHLOROBENZENE DERIVATIVES

The oxidative hydroxylation of benzene,phenol,chlorobenzene,and o-(m-,p-)dichlorobenzene was studied by using V2O5 catalyst,30%hydrogen peroxide as oxidant and acetic acid as solvent.The results showed that under the experimental conditions,the oxidation activity of phenol was significantly higher than that of benzene,but it was easy to lead to deep oxidation;the oxidation activity of chlorobenzene was slightly higher than that of benzene;the relative selectivity of para-position of chlorine in benzene ring was about 45 times of that of ortho-or meta-position in the oxidative hydroxylation of chlorobenzene;the selectivity in the oxidative hydroxylation of dichlorobenzene was affected by the two chlorines,and its relative selectivity of a certain position was roughly equivalent to the product of relative selectivity of each chlorine in its presence alone.