| 肟菌酯关键中间体的合成研究 |
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| 引用本文： | 吕坤志,刘媛媛,李杰,高尚,胡来凤,蒋露露,李方实.肟菌酯关键中间体的合成研究[J].精细化工,2014,31(10). |
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| 作者姓名： | 吕坤志 刘媛媛 李杰 高尚 胡来凤 蒋露露 李方实 |
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| 作者单位： | 南京工业大学,东南大学成贤学院,东南大学成贤学院,东南大学成贤学院,东南大学成贤学院,东南大学成贤学院,南京工业大学 |
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| 基金项目： | 江苏省自然科学基金青年基金项目(BK20130749)；江苏省大学生实践创新项目(scx1307)；东南大学成贤学院青年教师科研发展基金项目(7303600001) |
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| 摘 要： | 以邻甲基苯乙酮为原料，依次经相转移催化下的高锰酸钾碱性氧化、甲醇酯化、甲氧胺盐酸盐肟化和N-溴代丁二酰亚胺（NBS）溴化后，得到制备肟菌酯的关键中间体——(E)-2-(2'-溴甲基苯基)-2-羰基乙酸甲酯-O-甲基酮肟。产品结构经熔点和1H-NMR表征。通过优化反应条件，总收率可达52%。
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| 关 键 词： | 肟菌酯 邻甲基苯乙酮 氧化 酯化 肟化 溴化 |
| 收稿时间： | 2014/3/25 0:00:00 |
| 修稿时间： | 2014/6/30 0:00:00 |
Study on the Synthesis of Pivotal Intermediate of Trifloxystrobin |
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| LV Kun-zhi,LIU Yuan-yuan,Li Jie,Gao Shang,HU Lai-feng,Jiang Lu-lu and LI Fang-shi.Study on the Synthesis of Pivotal Intermediate of Trifloxystrobin[J].Fine Chemicals,2014,31(10). |
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| Authors: | LV Kun-zhi LIU Yuan-yuan Li Jie Gao Shang HU Lai-feng Jiang Lu-lu and LI Fang-shi |
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| Affiliation: | Nanjing Tech University,Southeast University ChengXian College,Southeast University ChengXian College,Southeast University ChengXian College,Southeast University ChengXian College,Southeast University ChengXian College,Nanjing Tech University |
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| Abstract: | The pivotal intermediate (E)-methyl 2-(2-(bromomethyl)phenyl)-2-(methoxyimino)acetate of Trifoxystrobin was synthesized from 2-methylacetophenone via a serial of reactions included alkaline oxidation with potassium permanganate in the presence of the phase-transfer catalyst, esterification with methanol, oximation with methoxyamine hydrochloride, bromination with N-bromosuccinimide (NBS). The structure was characterized by melting point and 1H-NMR. Under the optimized reaction conditions, the total yield was 52%. |
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| Keywords: | trifloxystrobin 2-methylacetophone oxidation esterification oximation bromination |
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