| Enantioselective extraction of terbutaline enantiomers by lipophilic tartaric acid |
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| 引用本文： | TANG,Ke-wen(唐课文),ZHOU,Chun-shan(周春山). Enantioselective extraction of terbutaline enantiomers by lipophilic tartaric acid[J]. 中南工业大学学报(英文版), 2003, 10(1): 44-48. DOI: 10.1007/s11771-003-0068-9 |
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| 作者姓名： | TANG Ke-wen(唐课文) ZHOU Chun-shan(周春山) |
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| 作者单位： | CollegeofChemistryandChemicalEngineeringCentralSouthUniversity，CollegeofChemistryandChemicalEngineeringCentralSouthUniversity Changsha410083，China，DepartmentofChemistryandChemicalEngineering，YueyangNormalUniversity，Yueyang414000，China，Changsha410083，China |
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| 基金项目： | TheNaturalScienceFoundationofHunanProvince(No.0 1JJY2 0 98) |
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| 摘 要： | 1 ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｃｈｉｒａｌｎａｔｕｒｅｏｆｌｉｖｉｎｇｓｙｓｔｅｍｓｈａｓｅｖ ｉｄｅｎｔｉｍｐｌｉｃａｔｉｏｎｓｏｎｂｉｏｌｏｇｉｃａｌｌｙａｃｔｉｖｅｃｏｍ ｐｏｕｎｄｓｉｎｔｅｒａｃｔｉｎｇｗｉｔｈｔｈｅｍ .Ｏｎａｍｏｌｅｃｕｌａｒｌｅｖｅｌ,ｃｈｉｒａｌｉｔｙｒｅｐｒｅｓｅｎｔｓａｎｉｎｔｒｉｎｓｉｃｐｒｏｐｅｒｔｙｏｆｂｕｉｌｄｉｎｇｓｕｂｓｔａｎｃｅｓｏｆｌｉｆｅ ,ｓｕｃｈａｓａｍｉｎｏａｃｉｄｓａｎｄｓｕｇａｒｅｔｃ.Ａｓａｒｅｓｕｌｔ,ｔｈｅｄｉｆｆｅｒｅｎｔｅｎａ…
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| 收稿时间： | 2002-07-15 |
Enantioselective extraction of terbutaline enantiomers by lipophilic tartaric acid |
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| Tang Ke-wen and Zhou Chun-shan. Enantioselective extraction of terbutaline enantiomers by lipophilic tartaric acid[J]. Journal of Central South University of Technology, 2003, 10(1): 44-48. DOI: 10.1007/s11771-003-0068-9 |
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| Authors: | Tang Ke-wen and Zhou Chun-shan |
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| Affiliation: | (1) College of Chemistry and Chemical Engineering, Central South University, 410083 Changsha, China;(2) Department of Chemistry and Chemical Engineering, Yueyang Normal University, 414000 Yueyang, China |
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| Abstract: | Distribution behavior of terbutaline enantiomers was examined in the aqueous and organic solvent of a two-phase system containing L-dibenzoyltartaric acid and lipophilic phase transfer reagent of Na-tetraphenylborate. The influences of pH, organic solvents, concentrations of Na-tetraphenylborate and L-dibenzoyltartaric acid on the partition coefficients and enantioselectivity of terbutaline enantiomers, were investigated. The results show that tetraphenylborate lipophilic anion and terbutaline enantiomers form two lipophilic salt complexes, which facilitates the solubility of the enantiomers in the organic phase. L-dibenzoyltartaric acid forms more stable complexes with enantiomer II than with enantiomer I. Enantioselectivity and partition coefficient increase with the addition of the length of alkyl chain of alcohols. pH and concentrations of lipophilic anion and L-dibenzoyltartaric acid influence them obviously and differently. Foundation item: The Natural Science Foundation of Hunan Province(No. 01JJY2098) Biography of the first author: TANG Ke-wen, doctoral student, born in 1970, majoring in applied chemistry. |
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| Keywords: | L dibenzoyltartaric acid terbutaline enantiomers chiral extraction |
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