| IBM SPSS Statistics优化3,5-二氯对氨基苯磺酰胺的合成 |
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| 引用本文： | 李红霞,刘瑞江,张业旺.IBM SPSS Statistics优化3,5-二氯对氨基苯磺酰胺的合成[J].计算机与应用化学,2011,28(11). |
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| 作者姓名： | 李红霞 刘瑞江 张业旺 |
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| 作者单位： | 江苏大学药学院,江苏,镇江,212013 |
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| 基金项目： | 江苏大学高级人才基金(No.11JDG056); 江苏省高校自然科学基金(09KJB530001) |
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| 摘 要： | 目的:使用IBM SPSS Statistics软件设计合成3,5-二氯对氨基苯磺酰胺,优化实验条件。方法:选择原料配比、H_2O_2用量、H_2O_2滴加时间三因素设计正交实验,将实验结果输入IBM SPSS Statistics软件,分析得到正交实验方差表和单因素统计表,并对实验数据进行统计分析,得到实验的优化条件。结果:3,5-二氯对氨基苯磺酰胺制备的最佳条件是:原料配比n(C_6H_6N_2O_2S):n(30%HCI质量分数)=1:17,H_2O_2用量1mol,H_2O_2滴加时间60min。收率达80.8%,熔点为204℃～205.5℃。结论:IBM SPSS Statistics软件具有强大的试验设计和数据统计分析功能,而且使用方便、计算精确、结论可靠,避免了大量人工计算,可以迅速分析出3,5-二氯对氨基苯磺酰胺有机合成工艺中的优化条件,值得在有机合成工艺优化中推广。
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| 关 键 词： | IBM SPSS Statistics 优化 3 5-二氯对氨基苯磺酰胺 合成 |
Preparation of 3,5-dichlorosulfanilamide by IBM SPSS statistics |
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| Li Hongxia,Liu Ruijiang,Zhang Yewang.Preparation of 3,5-dichlorosulfanilamide by IBM SPSS statistics[J].Computers and Applied Chemistry,2011,28(11). |
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| Authors: | Li Hongxia Liu Ruijiang Zhang Yewang |
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| Affiliation: | Li Hongxia~*,Liu Ruijiang and Zhang Yewang (School of Pharmaceutical Science,Jiangsu University,Zhenjiang,212013,Jiangsu,China) |
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| Abstract: | 3,S-dichlorosulfanilamide was designed and synthesized,experimental data was analyzed by IBM SPSS Statistics software.The orthogonal was designed by the effect of molar ratio,the amount of H_2O_2 and the addition time of H_2O_2,test results were inputted to the IBM SPSS Statistics software and analyzed,analysis of variance and statistics of single factor were got,and optimization conditions were determined as follows: n(C_6H_6N_2O_2S):(30%HCl)=1:17,the amount of H_2O_2 was 1.0 mol,the time needed for the ad... |
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| Keywords: | IBM SPSS were analyzed quickly so it is worth to popularize IBM SPSS Statistics in the technical optimization of organic synthesis statistics optimization 3 5-dichlorosulfanilamide preparation |
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