| Abstract: | It was intendet to characterize the isoenzymes of serum alkaline phosphatase in healthy infants. Quantitative estimation of the activity of serum alkaline phosphatase resulted in relatively low values in the newborns and a distinct increase during the first three months of live. As a rule most of the newborns appeared to present one uniform isoenzyme fraction, which was comparable to the isoenzyme of bone origin of the adult. Some of the newborns already exhibited another less marked isoenzyme, the isoenzyme of liver origin. During babyhood this isoenzyme becomes more and more distinct. In most cases this development had become perfect at the end of the first year. Liver tissue of newborns apparently does not synthesize the same liver isoenzyme as liver tissue of adults. |
