| 2-氯-5-甲基噻吩的合成 |
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| 引用本文： | 张央.2-氯-5-甲基噻吩的合成[J].精细化工中间体,2010,40(2):41-43. |
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| 作者姓名： | 张央 |
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| 作者单位： | 徐州市人元医药化工有限公司,研发科,江苏,徐州,221400 |
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| 摘 要： | 以噻吩为原料,经甲酰化,还原制得2-甲基噻吩,2-甲基噻吩经硫酰氯氯化制备2-氯-5-甲基噻吩。通过实验获得反应的优化条件,在此条件下的收率为73.84%。
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| 关 键 词： | 2-噻吩甲醛 2-甲基噻吩 2-氯-5-甲基噻吩 |
Synthesis of 2-Cldoro-5-methyithiophene |
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| ZHANG Yang.Synthesis of 2-Cldoro-5-methyithiophene[J].Fine Chemical Intermediates,2010,40(2):41-43. |
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| Authors: | ZHANG Yang |
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| Affiliation: | ZHANG Yang (Research and Development Department of Xuzhou Renyuan Pharmaceutical Chemicals Co., Ltd, Xuzhou 221400, China) |
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| Abstract: | 2-Chloro-5-methyhhiophene （1） is a versatile intermediate for the synthesis of pharmaceuticals and agrochemicals. A facile and low-cost route for the preparation of 1 was reported through the reaction of 2- methylthiophene with sulfuryl chloride. The process produced the product in 73.96% yield. |
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| Keywords: | 2-thiophenecarboxaldehyde 2-methyhhiophene 2-chloro-5-methylthiophene |
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