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"Amphetamine sensitization: Nonassociative and associative components": Correction to Wang and Hsiao (2003).
Authors:Wang  Ying-Chou; Hsiao  Sigmund
Abstract:Reports an error in "Amphetamine sensitization: Nonassociative and associative components" by Ying-Chou Wang and Sigmund Hsiao (Behavioral Neuroscience, 2003Oct], Vol 1175], 961-969). The institutional affiliation for Ying-Chou Wang is incomplete. The correct affiliation is Ching Kuo Institute of Management and Health and National Chung Cheng University. (The following abstract of the original article appeared in record 2003-08567-009.) Rats, pretreated with amphetamine (AMPH, 1 mg/kg) or saline for 2 weeks, were challenged with AMPH (0.5 mg/kg) or saline following 1 week of abstinence, and locomotion was measured. In Experiments 1 and 2, the pretreatment occurred in various contexts (home cage, novel box, test box). Sensitization was observed only when pretreatment context and test context were the same; a context switch abolished sensitization. When rats anesthetized with chloral hydrate were pretreated with AMPH, sensitization was completely dependent on the pretreatment, but independent of context. This "zero context" condition isolated the basal level of excitation attributable to unconditioned neural change to determine the role of contextual input to be a modulator that enhances or inhibits sensitization. (PsycINFO Database Record (c) 2010 APA, all rights reserved)
Keywords:amphetamine  drug sensitization  rats  chloral hydrate  contextual input  drug pretreatment  locomotion
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