Composite organic-inorganic nanoparticles as Raman labels for tissue analysis |
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| Authors: | Sun Lei Sung Kung-Bin Dentinger Claire Lutz Barry Nguyen Lienchi Zhang Jingwu Qin Haoyu Yamakawa Mineo Cao Manqiu Lu Yu Chmura A J Zhu Jing Su Xing Berlin Andrew A Chan Selena Knudsen Beatrice |
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| Affiliation: | Biomedical/Life Sciences, Digital Health Group, Intel Corporation, SC3-41, 2200 Mission College Boulevard, Santa Clara, California 95054, USA. |
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| Abstract: | Composite organic-inorganic nanoparticles (COINs) are novel optical labels for detection of biomolecules. We have previously developed methods to encapsulate COINs and to functionalize them with antibodies. Here we report the first steps toward application of COINs to the detection of proteins in human tissues. Two analytes, PSA and CK18, are detected simultaneously using two different COINs in a direct binding assay, and two different COINs are shown to simultaneously label PSA in tissue samples. |
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