| 液相色谱质谱法检测化妆品中的丙烯酰胺 |
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| 引用本文： | 矫筱蔓,郭春梅,庞燕军,齐晓飞.液相色谱质谱法检测化妆品中的丙烯酰胺[J].香料香精化妆品,2011(4):33-35. |
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| 作者姓名： | 矫筱蔓 郭春梅 庞燕军 齐晓飞 |
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| 作者单位： | 辽宁省食品药品检验所,沈阳,110023 |
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| 摘 要： | 建立化妆品中丙烯酰胺残留量的液相色谱-串联质谱的检测方法。化妆品样品用0．1％甲酸溶液振摇提取，用石油醚除去基质，取下层清液高速离心后过滤，用液相色谱分离，采用质谱检测器对化妆品中丙烯酰胺进行检测，以标准曲线法定量分析。方法检出限为0．031ug／g，定量限为0．1ug／g，在10-500ng／mL范围内呈良好的线性关系，3个添加水平范围的平均回收率为92．6％～109．1％，精密度RSD=1．24%，重复性RSD=1．7％。该方法能够满足化妆品中丙烯酰胺残留的检测要求。
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| 关 键 词： | 丙烯酰胺 化妆品 液相色谱-串联质谱法 |
Determination of Acrylamide Residue in Cosmetics by HPLC-MS/MS |
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| JIAO Xiaoman,GUO Chunmei,PANG Yanjun,QI Xiaofei.Determination of Acrylamide Residue in Cosmetics by HPLC-MS/MS[J].Flavour Fragrance Cosmetics,2011(4):33-35. |
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| Authors: | JIAO Xiaoman GUO Chunmei PANG Yanjun QI Xiaofei |
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| Affiliation: | JIAO Xiaoman GUO Chunmei PANG Yanjun QI Xiaofei(The Institute for Food and Drug Control of Liaoning Province,Shenyang 110023,China) |
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| Abstract: | A comprehensive analytical method based on LC-MS/MS has been developed for the determination of acrylamide residue in cosmetics.Cosmetic sample was extracted with 0.1% formic acid,and petroleum ether was used to remove matrix.After taking the lower serum with high-speed centrifuge and filter,the obtained liquid was separated by liquid chromatography,and used mass spectrometry to detect the acrylamide residue in cosmetics,then used the standard curve to conduct quantitative analysis.The limit of detection fo... |
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| Keywords: | acrylamide cosmetics liquid chromatography-tandem mass spectrometry(LC-MS/MS) |
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