Agglomeration behavior of anhydrous L-ornithine-L-aspatate crystals during semi-batch drowning-out crystallization |
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Authors: | Woochan Hyung Yehoon Kim Seungjoo Haam Kee-Kahb Koo |
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Affiliation: | (1) Department of Chemical Engineering, Yonsei University, 120-749 Seoul, Korea;(2) Department of Chemical and Biomolecular Engineering, Sogang University, 121-742 Seoul, Korea |
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Abstract: | Crystallization of L-ornithine-L-aspartate (LOLA) by drowning out was carried out to produce the anhydrous form of agglomerates.
The primary crystal size in the agglomerate remained unchanged after completion of the crystallization. The LOLA aqueous solution
introduced into the system was immediately dispersed and cluster coagulated on the surface of the crystals. On the surface
of the crystals, a cluster reached critical nuclei size, nucleated and intergrowth to form agglomerates. It was proposed that
a spherical agglomeration occurred during secondary nucleation by coagulation model and intergrowth. The agglomerates size
and size distribution were varied with the process parameters. The agglomerate sizes of LOLA crystals appeared to be ruled
not only by secondary nucleation rate but also by the mass of suspended agglomerates. Moreover, the agglomeration rates of
fine particles were higher than the agglomeration rates of large agglomerates. Using these properties, the uniform agglomerates
size distribution could be obtained. |
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Keywords: | Drowning-Out L-Ornithine-L-Aspartate Pseudopolymorph Agglomeration Impurity |
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