| Affiliation: | 1. Department of Chemistry, School of Chemical Science and Technology, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, MP, 470003 India These authors contributed equally to this work.;2. Department of Microbiology, CSIR-Central Drug Research Institute, Sitapur Road, Janakipuram Extension, Lucknow, India;3. Department of Chemistry, School of Chemical Science and Technology, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, MP, 470003 India |
| Abstract: | The microbiota-gut-brain axis (GBA) plays a critical role in the development of neurodegenerative diseases. Dysbiosis of the intestinal microbiome causes a significant alteration in the gut microbiota of Alzheimer's disease (AD) patients, followed by neuroinflammatory processes. Thus, AD beginning in the gut is closely related to an imbalance in gut microbiota, and hence a multidomain approach to reduce this imbalance by exerting positive effects on the gut microbiota is needed. In one example, a tyrosine-based short peptide amphiphile (sPA) was used to synthesize antibacterial AgNPs−sPA nanostructures. Such nanostructures showed high biocompatibility and low cytotoxicity, and therefore work as model drug delivery agents for addressing local bacterial infections. These may have therapeutic value for the treatment of microbiota-triggered progression of neurodegenerative diseases. |
