Mechanosynthesis of Triazolyl-bis(indolyl)methane Pharmacophores via Gold Catalysis: A Prelude to Their Molecular Electronic Properties and Biological Potency |
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Authors: | Ramachandran Sundaramoorthy Dr. Murugan Vadivelu Prof. Dr. Kesavan Karthikeyan Prof. Dr. Chandrasekar Praveen |
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Affiliation: | 1. Department of Chemistry, B. S. Abdur Rahman Crescent Institute of Science and Technology, Chennai, 600048 Tamil Nadu, India;2. Electrochemical Power Sources Division, CSIR-Central Electrochemical Research Institute, Karaikudi, 630003 Tamil Nadu, India |
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Abstract: | Chemical structures possessing both 1,2,3-triazole and bis(indolyl)methane fragments gained considerable interest in drug synthesis owing to their established biological efficacies. However, 1,2,3-triazoles linked at the bridging position of bis(indolyl)methane is a logical and unexplored design approach. In this regard, nine new triazolyl-bis(indolyl)methane conjugates under AuCl catalyzed ball-milling conditions were accomplished. Comparative evaluation on absorptive and emissive properties of the synthesized dyads were also analyzed. To unravel the influence of different peripheral substituents on the electronic structure and π-orbital properties, theoretical investigations were performed. Screening of molecules for free radical scavenging, anti-inflammatory and antidiabetic showed comparable potency against reference drugs. In particular, compounds 7 h , 7 d and 7 a displayed good efficiency of α-amylase inhibition. The DNA gyrase inhibitory potential of all compounds were assessed in silico which revealed high binding affinity (ΔG=−8.99 Kcal/mol) for 7 i followed by 7 h (ΔG=−7.80 Kcal/mol) with the targeted protein. |
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Keywords: | triazolyl-bis(indolyl)methanes mechanosynthesis π-orbital properties biological screening molecular docking |
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