Recent Advances in Strategies for Imaging Detection and Intervention of Cellular Senescence |
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Authors: | Jili Li Zhengyan Bi Linlin Wang Yinghao Xia Yuqi Xie Prof Yanlan Liu |
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Affiliation: | Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan University, Changsha, Hunan, 410082 P. R. China |
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Abstract: | Cellular senescence is a stable cell cycle arrest state that can be triggered by a wide range of intrinsic or extrinsic stresses. Increased burden of senescent cells in various tissues is thought to contribute to aging and age-related diseases. Thus, the detection and interventions of senescent cells are critical for longevity and treatment of disease. However, the highly heterogeneous feature of senescence makes it challenging for precise detection and selective clearance of senescent cells in different age-related diseases. To address this issue, considerable efforts have been devoted to developing senescence-targeting molecular theranostic strategies, based on the potential biomarkers of cellular senescence. Herein, we review recent advances in the field of anti-senescence research and highlight the specific visualization and elimination of senescent cells. Additionally, the challenges in this emerging field are outlined. |
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Keywords: | age-related diseases analytical methods cellular senescence molecular probes senescence imaging |
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