Integrated PLGA–Ag nanocomposite systems to control the degradation rate and antibacterial properties |
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Authors: | Silvia Rinaldi Elena Fortunati Marco Taddei Josè M. Kenny Ilaria Armentano Loredana Latterini |
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Affiliation: | 1. Dipartimento di Chimica and Centro di Eccellenza sui Materiali Innovativi Nanostrutturati (CEMIN), Università di Perugia Via Elce di Sotto 8, , 06123 Perugia, Italy;2. Centro di Ingegneria dei Materiali UdR INSTM, NIPLAB, Università di Perugia, , Terni, Italy;3. Institute of Polymer Science and Technology CSIC, Juan de la Cierva 3, , 28006 Madrid, Spain |
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Abstract: | Biodegradable polymer based nanocomposite materials have attracted much attention since they can be used for biomedical and pharmaceutical applications. In order to have highly integrated PLGA nanocomposite materials, silver colloidal nanoparticles were prepared in chloroform starting from silver nitrate and using polyvinylpyrrolidone as reduction and capping agent. TEM and AFM imaging give information on the size distribution of the silver nucleus (7.0 nm) and the capping shell (8.2–10.7 nm). PLGA–Ag nanocomposites were prepared upon addition of 1 or 3% wt of silver nanoparticles to the PLGA/chloroform suspension. The effect of silver loading on polymer degradation was studied following the mass loss and the morphology of nanocomposite films at different degradation stages. The concentrations of Ag+, which is released during nanocomposite degradation, were monitored and analyzed through the diffusion model, to have insight on the degradation kinetics. The release rate, and likely the degradation rate, was reduced at higher silver loading. Bacterial growth tests indicated that the cell growth is inhibited in the presence of PLGA–Ag nanocomposites and the efficiency is correlated to Ag+ release. Thus, controlling the nanoparticle loading, a tunable degradation and antibacterial action can be designed. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 1185‐1193, 2013 |
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Keywords: | nanoparticles nanowires and nanocrystals biodegradable composites degradation biomedical applications |
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