An analysis of the intracerebral ability to eliminate a nitroxide radical in the rat after administration of idebenone by anin vivo rapid scan electron spin resonance spectrometer |
| |
Authors: | Hidekatsu Yokoyama Nobuaki Tsuchihashi Tateaki Ogata Midori Hiramatsu Norio Mori |
| |
Affiliation: | (1) Institute for Life Support Technology, Yamagata Technopolis Foundation, 2-2-1, Matsuei, 990 Yamagata, Japan;(2) Fukushima Medical College, 960-12 Fukushima, Japan;(3) Faculty of Engineering, Yamagata University, 992 Yonezawa, Japan;(4) Hamamatsu University School of Medicine, 431-31 Hamamatsu, Japan |
| |
Abstract: | Electron spin resonance (ESR) measurements after intracerebroventricular injection of a nitroxide radical were carried out in rats (n=6) that received oral idebenone for 2 weeks and in control rats (n=5), using anin vivo rapid scan ESR spectrometer. The half-life of nitroxide, which was estimated from the change in the peak height ( M=+1) of the ESR signals from the head, was used as a marker for the elimination of the nitroxide radical. The half-life in the rats treated with idebenone was significantly shorter than it was in the controls (p<0.05). This finding indicates that the treatment with idebenone can enhance the intracerebral-eliminating ability of the nitroxide radical. |
| |
Keywords: | free radical in vivo electron spin resonance rapid scan nitroxide radical idebenone brain |
本文献已被 SpringerLink 等数据库收录! |
|