Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanoparticles: comparison with conventional monocultures |
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Authors: | Kasper Jennifer Hermanns Maria I Bantz Christoph Maskos Michael Stauber Roland Pohl Christine Unger Ronald E Kirkpatrick James C |
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Affiliation: | (1) University Medical Centre, Institute of Pathology, Mainz, Germany;(2) Johannes Gutenberg University Mainz, Institute of Physical Chemistry, Mainz, Germany;(3) BAM Bundesanstalt f?r Materialforschung und -pr?fung, Berlin, Germany;(4) Molecular and Cellular Oncology, ENT Department, University Medical Centre, Mainz, Germany |
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Abstract: | Background To date silica nanoparticles (SNPs) play an important role in modern technology and nanomedicine. SNPs are present in various
materials (tyres, electrical and thermal insulation material, photovoltaic facilities). They are also used in products that
are directly exposed to humans such as cosmetics or toothpaste. For that reason it is of great concern to evaluate the possible
hazards of these engineered particles for human health. Attention should primarily be focussed on SNP effects on biological
barriers. Accidentally released SNP could, for example, encounter the alveolar-capillary barrier by inhalation. In this study
we examined the inflammatory and cytotoxic responses of monodisperse amorphous silica nanoparticles (aSNPs) of 30 nm in size
on an in vitro coculture model mimicking the alveolar-capillary barrier and compared these to conventional monocultures. |
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