神经元钙振荡的非线性动力学研究

在神经元的生理实验中经常观察到丰富的钙振荡模式,本文详细综述了产生这些现象的钙流交换机理和各类通道调节机理,以及描述这些生理机理的数学表达式.介绍三类典型的研究钙振荡的非线性动力学模型,即电压动力学与钙动力学相耦合的模型,多个钙存储单元之间钙流平衡的模型和考虑信使物质IP3的振荡与钙振荡相互作用的模型;并针对第一个模型简要地讨论其复杂的动力学行为;最后对神经元钙振荡的非线性动力学研究提出了一些展望.

Nonlinear dynamics of calcium oscillations in neurons

Rich calcium oscillation patterns are frequently observed in neuronal physiological experiments.Various mechanisms for generating these phenomena,including exchanging among calcium storing compartments(such as cellular cytosol,endoplasmic reticulum,mitochondria and calcium binding proteins)and regulating roles of different types of calcium channels,were summarized,and the mathematical expressions of these mechanisms were given.Three representative nonlinear dynamical models of calcium oscillations were introduced in order to concern the coupling with voltage dynamics,the exchange of calcium fluxes,and the oscillation of the messenger IP3,respectively.Complex dynamical behaviors were discussed with regard to the first model,which is of importance for neuroscience.Conclusions and some proposals were presented for the study of nonlinear dynamics of neuronal calcium oscillations in the future.